AB0164 THE EFFECT OF RHEUMATOID ARTHRITIS ON FEMALE FERTILITY

Background: Infertility is a disease of the reproductive system defined by failure to achieve clinical pregnancy after 12 months or more regular unprotected sexual intercourse. Although rheumatoid arthritis (RA) tends have late onset, also occurs during child-bearing years and may interfere with procreation. Objectives: The aim this study was compare fertility rates in women RA birth-year-matched references from general population. Methods: This case-control study. Menopausal married who were diagnosed department Rheumatology at Hedi Chaker Hospital before age forty recruited into as cases apparently healthy matched controls. Demographic, clinical, immunological, radiological therapeutic data collected each case using medical record patient. Data obtained included age, duration RA, extra-articular manifestations, Rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (ACPA), presence erosions on radiographs hands feet therapy. controls asked state their menstrual regularity, menarche, menopause, gestity, parity, number living children, time first pregnancy, primary secondary infertility, interpregnancy interval, miscarriage utero foetal death (IUFD) preterm delivery number. Results: mean ages 54 ± 8,11 [39, 69]. median since onset patients 22,5 10,53 [1, 47]. 31,4 6,3 [18, 39] years. Forty-nine percent (49%) patient had manifestations: ocular sicca syndrome 43,8% cases, pulmonary fibrosis 5,3% nodules 1,8 % cases. (RF) present 61,4% while anti-CCP anti-body 59,6% Erosive polyarthritis found 80,7% patients. rate RF 319,7 462,4 UI/ml 185,8 264. Women statistically significant longer than control group. Primary infertility seen 15 (26,3%) 2 (3,5%) controls, whereas 31 (54,5%) (3,5 %) significantly likely infertility. There no differences gestity parity between two groups. menopause lower group Conclusion: Our showed that are reduced cannot definitively address issue impaired among results suggestive enough warrant further research link takes women’s childbearing choices account. References: [1]Clowse ME, Chakravarty E, Costenbader KH, Chambers C, Michaud K. Effects loss, concerns family size systemic lupus erythematosus. Arthritis Care Res 2012; 64: 668-74. [2]Brouwer J, Hazes JM, Laven JS, Dolhain RJ. Fertility arthritis: influence activity medication. Ann Rheum Dis 2015; 74: 1836-41. [3]Pope JE, Bellamy N, Stevens A. lack associations both nulliparity Semin 1999; 28:34250. [4]Akintayo RO, Aworinde O, Ojo Akintayo FC, Akinlade OM, Awodun Isa SO. Is an innocent bystander female problems? A comparative Nigerian without arthritis. Eur J Rheumatol 2018; 5(3): 179-83. Disclosure Interests: None declared